Definitely not stock. The only way to know if they would fit is to measure the backspace (assuming they are the correct bolt pattern). A standard c3 can accommodate a 4" backspace. In original form, the 8" wheel with a 4" backspace put the mounting hub exactly in the center of the wheel, presumably to balance the load on the hub bearings. Going with a 10" wheel will load the outer bearing more than the inner bearing. It's not a huge deal but be weary of bearing wear. Others that have the big wheels and fenders can chime in.
The best way to know, obviously, is to fit them. If that's not an option, your best bet is to take measurements. First, verify the bolt pattern is the same. As I recall our cars use a 5x4.5" pattern, but you have to be aware that Chevy used several different patterns for different applications and you cannot just "eyeball" measure them. The other major measurement is to lay a flat surface across the back of the rim (2x4 or something similar) and then measure the depth from that to the back of the mounting surface. It should be 4" to fit without hitting the trailing arm. You could possibly be OK at 4.5", but I suspect the tire might contact the trailing arm. Anything greater than 4.5" will guarantee modifications to fit correctly. Anything less and you really start putting some additional load on the bearings, plus you'll have to deal with a wheel/tire that sticks out considerably from the fender.
I think a 295 should fit just fine on a 10" rim.
Now that I've said all that, I personally think you should save your money and find a set of 16" or 17" (or 18") wheels that fit your taste. Your tire selection is going to be far better now and the prices are getting pretty reasonable. It won't be long before you are going to have to special order a 15" tire wider than 6" from a specialty manufacturer. And then, the 17" tires on the shelf are going to be cheap by comparison.